Ipswich will be without goalkeeper Marton Fulop and striker Tamas Priskin after the pair were called up by Hungary for the England friendly.
Winger Carlos Edwards faces several weeks on the sidelines after going off with a groin injury at the weekend.
MATCH FACTS
Head-to-head
• These clubs have faced each other 25 times. Exeter have won six, Ipswich 10, with nine finishing all square.
• The Devon club have not beaten Ipswich on home territory since 1951.
• The only previous time the sides were paired together in the League Cup saw Ipswich win 6-2 on aggregate in the first round in 1998.
Have your say on the game
Exeter
• The Grecians last won a League Cup tie in 1993. They have suffered 11 first-round defeats since then, either side of a five-year exile from the Football League.
• The Grecians have never been beyond the fourth round.
• It is 17 years since Exeter last won a League Cup match on home territory.
Ipswich
• The Blues have never appeared in the League Cup final, but have been semi-finalists three times. The most recent was in 2001.
• Ipswich last won a League Cup match on the road nine years ago. They knocked out Crewe 3-2 in the third round at Gresty Road in October 2001.
• This tie is being staged on Roy Keane's 39th birthday.
Source: BBC Sport
Source: BBC Sport